Antimicrobials
Eravacycline

Eravacycline

Restricted

Low
N/A
$$$ ($101-$200/day)

Spectrum of Activity

General Information

  • Infusion site reactions

  • N/V/D

CYP3A4 Inducers (Strong): 

May decrease the serum concentration of Eravacycline.

  • Management: Increase the eravacycline dose to 1.5 mg/kg every 12 hours when combined with strong CYP3A4 inducers
  • Distribution: Vdss: 321 L (4 L/kg)
  • Protein Binding: 79% to 90% (increases with increasing plasma concentrations)
  • Metabolism: Primarily by CYP3A4- and FMO-mediated oxidation
  • Half-Life Elimination: 20 hours
  • Excretion
    • Urine: ~34% (20% as unchanged drug)
    • Feces: 47% (17% as unchanged drug)