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Antimicrobials
Ciprofloxacin

Ciprofloxacin

High
Good (70 to 90%)
$ (<$25/day)

General Information

  • Aortic aneurysm/aortic dissection

  • CNS effects/neuroexcitation

  • Clostridioides difficile infection

  • Glucose regulation/dysglycemia

  • Hepatotoxicity

  • Hypersensitivity reactions (immediate and delayed)

  • Myasthenia gravis

  • Peripheral neuropathy

  • Phototoxicity/photoallergy

  • QT prolongation

  • Tendinopathy/tendon rupture

  • Absorption: Well-absorbed
  • Distribution:
    • Vd: 2.1 to 2.7 L/kg
    • Tissue concentrations often exceed serum concentrations especially in kidneys, gallbladder, liver, lungs, gynecological tissue, and prostatic tissue
    • CSF concentrations: 10% of serum concentrations (noninflamed meninges), 14% to 37% (inflamed meninges)
  • Protein Binding: 20%-40%
  • Metabolism: Partially hepatic
  • Bioavailability: 70%
  • Half-Life Elimination: 4-6 hrs
  • Excretion: 
    • Urine (35% to 70% as unchanged drug)
    • Feces (15% to 35%; <1% as unchanged drug)