Restricted
Serum creatinine and urine protein (at baseline and within 48 hours of each dose)
WBC with differential (prior to each dose)
Intraocular pressure and visual acuity
Signs and symptoms of uveitis/iritis
Metabolic acidosis
Headache
Pain
Skin rash
Skin discoloration
Fanconi's syndrome
Diarrhea, nausea, vomiting
Oral candidiasis
Abdominal pain
Proteinuria
Urinary incontinence
Neutropenia
Hypochromic anemia
Iritis, uveitis
Dyspnea
Cladribine: Agents that Undergo Intracellular Phosphorylation may diminish the therapeutic effect of Cladribine. Risk X: Avoid combination.
Tenofovir Products: Cidofovir may increase the serum concentration of Tenofovir Products. Tenofovir Products may increase the serum concentration of Cidofovir.
NOT PART OF TAMPA's RENAL DOSING PROTOCOL
To minimize the likelihood of nephrotoxicity, unless otherwise indicated, premedicate with probenecid 2 g 3 hours prior to the cidofovir dose, then 1 g 2 hours and 8 hours after completion of the infusion.
Patients should also receive 1 L of NS IV infused over 1 to 2 hours immediately prior to each cidofovir infusion.
If tolerated, a second liter may be administered over 1 to 3 hours at the start of cidofovir infusion or immediately following infusion.
With Probenecid:
Clearance: