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Antimicrobials
Ceftriaxone

Ceftriaxone

High
N/A
$ (<$25/day)

Dosing

General Information

  • Ceftriaxone-calcium precipitation

  • Hemolytic anemia

  • Kernicterus

Calcium Salts (Intravenous):

  • May enhance the adverse/toxic effect of CefTRIAXone

  • Ceftriaxone binds to calcium forming an insoluble precipitate

  • Management: Use of ceftriaxone is contraindicated in neonates (28 days of age or younger) who require (or are expected to require) treatment with IV calcium-containing solutions

  • In older patients, flush lines with compatible fluid between administration

  • Risk D: Consider therapy modification

Rocephin

NOT recommended for S. aureus infections

  • Distribution: Widely throughout the body including gallbladder, lungs, bone, bile, CSF (higher concentrations achieved when meninges are inflamed)
  • Vd: ~6-14 L
  • Protein Binding: 85% to 95%
  • Half-Life Elimination: ~5-9 hrs
  • Excretion: 
    • Urine (33% to 67% as unchanged drug)
    • Feces (as inactive drug)