Antimicrobials
Ceftolozane/Tazobactam

Ceftolozane/Tazobactam

Restricted

High
N/A
$$$$ ($201-$500/day)

Spectrum of Activity

General Information

Renal function

Increased serum transaminases

  • Distribution: Vd
    • Ceftolozane: 13.5 L
    • Tazobactam: 18.2 L
  • Protein Binding
    • Ceftolozane: 16% to 21%
    • Tazobactam: 30%
  • Metabolism
    • Ceftolozane: Not metabolized
    • Tazobactam: Hydrolyzed to inactive metabolite
  • Half-Life Elimination
    • Ceftolozane: ~3-4 hours
    • Tazobactam: ~2-3 hours
  • Excretion
    • Ceftolozane: Urine (>95% as unchanged drug)
    • Tazobactam: urine (>80% as unchanged drug)