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Antimicrobials
Ceftolozane/Tazobactam

Ceftolozane/Tazobactam

Restricted

High
N/A
$$$$ ($201-$500/day)

Spectrum of Activity

General Spectrum of Activity
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General Information

Renal function

Increased serum transaminases

  • Distribution: Vd
    • Ceftolozane: 13.5 L
    • Tazobactam: 18.2 L
  • Protein Binding: 
    • Ceftolozane: 16% to 21%
    • Tazobactam: 30%
  • Metabolism: 
    • Ceftolozane: Not metabolized
    • Tazobactam: Hydrolyzed to inactive metabolite
  • Half-Life Elimination: 
    • Ceftolozane: ~3-4 hours
    • Tazobactam: ~2-3 hours
  • Excretion: 
    • Ceftolozane: Urine (>95% as unchanged drug)
    • Tazobactam: urine (>80% as unchanged drug)