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Antimicrobials
Ceftazidime/Avibactam

Ceftazidime/Avibactam

Restricted

High
N/A
>$500/day

Spectrum of Activity

General Spectrum of Activity
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General Information

Renal function

Positive direct coombs test

  • Probenecid: May increase the serum concentration of Avibactam

  • Risk X: Avoid combination

  • Distribution: Vd:
    • Ceftazidime: 17 L
    • Avibactam: 22.2 L
  • Protein Binding:
    • Ceftazidime: <10%
    • Avibactam: 5.7% to 8.2%
  • Metabolism:
    • Ceftazidime: ~80% to 90% of dose eliminated as unchanged drug
    • Avibactam: Not metabolized
  • Half-Life Elimination: 2.7 hrs
  • Excretion:
    • Ceftazidime: Urine (~80% to 90% as unchanged drug)
    • Avibactam: Urine (97%)