Antimicrobials
Ceftaroline

Ceftaroline

Restricted

High
N/A
$$$$ ($201-$500/day)

Spectrum of Activity

General Information

Positive direct Coombs test

  • Distribution: Vd: Median: 20.3 L (range: 18.3-21.6 L)
  • Protein Binding: ~20%
  • Metabolism:
    • Ceftaroline fosamil (inactive prodrug) undergoes rapid conversion to bioactive ceftaroline in plasma by phosphatase enzyme
    • Ceftaroline is hydrolyzed to form inactive ceftaroline M-1 metabolite
  • Half-Life Elimination:
    • Single dose: 1.6 ± 0.38 hours
    • Multiple dose: 2.66 ± 0.4 hours
  • Time to Peak: ~1 hour
  • Excretion:
    • Urine (88%)
    • Feces (6%)