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Antimicrobials
Cefpodoxime

Cefpodoxime

High
Moderate (40 to 70%)
$ (<$25/day)

Spectrum of Activity

General Spectrum of Activity
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Dosing

General Information

Renal function

  • Absorption:
    • Rapid and well absorbed (50%)
    • Tablet AUC increased 21% to 33% with food
  • Distribution:
    • Good tissue penetration, including lung and tonsils
    • Penetrates into pleural fluid
  • Protein Binding:
    • Serum: 22% to 33%
    • Plasma: 21% to 29%
  • Metabolism: De-esterified in GI tract to active metabolite, cefpodoxime
  • Bioavailability: Oral: 50%
  • Half-Life Elimination: 2-3 hours
    • Prolonged with renal impairment (10 hours for CrCl <30 mL/minute)
  • Time to Peak:
    • Tablets: Within 2-3 hours
    • Oral suspension: Slower in presence of food, 48% increase in Tmax
  • Excretion: Urine (~29% to 33% as unchanged drug)