Antimicrobials
Cefepime

Cefepime

High
N/A
$ (<$25/day)

Dosing

General Information

Renal function

  • Positive direct Coombs test 
  • Neurotoxicity

Maxipime

  • Distribution:
    • Vd: 18 L, 0.26 L/kg
    • Penetrates into inflammatory fluid at concentrations ~80% of serum concentrations and into bronchial mucosa at concentrations ~60% of plasma concentrations
    • Crosses the blood-brain barrier
  • Protein Binding, Plasma: ~20%
  • Metabolism: Minimally hepatic
  • Half-Life Elimination:
    • 2 hrs
    • HD: 13.5 hrs
  • Excretion: Urine (85% as unchanged drug)