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Antimicrobials
Aztreonam

Aztreonam

Medium
N/A
$$ ($26-$100/day)

General Information

  • Neutropenia

  • Increased LFTs

  • Pain at injection site

  • Distribution: Widely into body tissues, cerebrospinal fluid, bronchial secretions, peritoneal fluid, bile, and bone
  • Vd: 0.15 to 0.18 L/kg
  • CSF:Blood Level Ratio:
    • Inflamed Meninges: 8% to 40%
    • Normal Meninges: ~1%
  • Protein Binding: 56%
  • Metabolism: Hepatic (minor %)
  • Half-Life Elimination: 
    • 1.5 to 2 hrs
    • ESRD: 6 to 8.4 hrs
  • Excretion:
    • Urine (60% to 70% as unchanged drug)
    • Feces (~12%)