Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate (40 to 70%)
$ (<$25/day)

Spectrum of Activity

Dosing

General Information

  • LFTs

  • CBC

  • QTc

  • Audiogram with prolonged use

  • Prolonged QT interval, polymorphic ventricular tachycardia

  • Drug-induced liver injury

  • Hypersensitivity reactions

  • Diarrhea, nausea

Zithromax

  • Absorption: Rapid from the GI tract
  • Distribution:
    • Extensive tissue
    • Distributes well into skin, lungs, sputum, tonsils, and cervix
    • Penetration into CSF is poor
  • Vd: 31-33 L/kg
  • Protein Binding: 7% to 51%
  • Metabolism: Hepatic to inactive metabolites
  • Bioavailability: 34% to 52%
  • Half-Life Elimination: 68-72 hours
  • Time to Peak, Serum: ~2-3 hours
  • Excretion:
    • Biliary (major route 50%, unchanged)
    • Urine (6% to 14% unchanged)