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Antimicrobials
Ampicillin/Sulbactam

Ampicillin/Sulbactam

Medium
N/A
$ (<$25/day)

Dosing

General Information

With prolonged therapy, monitor hematologic, renal, and hepatic function

Pain at injection site (with IM administration)

Ampicillin:

  • See Ampicillin monograph

Sulbactam:

  • Distribution:
    • Widely distributed to bile, blister, and tissue fluids
    • Poor penetration into CSF with uninflamed meninges
    • Higher concentrations attained with inflamed meninges
  • Vd: 0.25 L/kg
  • Protein Binding: 38%
  • Half-Life Elimination: 1-1.3 hours
  • Excretion: Urine (~75% to 85% as unchanged drug) within 8 hours