AdventHealth Tampa logo
Antimicrobials
Ampicillin

Ampicillin

Medium
Moderate (40 to 70%)
IV: $$ ($26-$100/day)

Dosing

General Information

  • Allergic reactions

  • Diarrhea, nausea, vomiting

For oral therapy, including oral step-down therapy after IV ampicillin, oral amoxicillin is preferred over oral ampicillin due to improved bioavailability and absorption

  • Absorption: Oral: 50%
  • Distribution:
    • Into bile
    • Penetration into CSF occurs with inflamed meninges only
  • Protein Binding: 15% to 18%
  • Half-Life Elimination:
    • 1-1.8 hours
    • Anuric patients: 8-20 hours
  • Time to Peak Serum Concentration: Oral: Within 1-2 hours
  • Excretion:
    • Urine (∼90%, unchanged within 24 hours)
    • Feces