Acyclovir
Adult

Adult

Note

IV Dosing
  • Use IBW, except for obese patients use AdjBW
  • Adult Standard Dose Rounding: nearest 50 mg

IV Dosing: Disseminated HSV, CNS Infection, Herpes Zoster, Varicella Zoster

Standard Dose

10 mg/kg IV q8hr

CrCL 25-50 mL/min/1.73 m²

10 mg/kg IV q12hr

CrCL 10-24 mL/min/1.73 m²

10 mg/kg IV q24hr

CrCL <10 mL/min/1.73 m² or HD

5 mg/kg IV q24hr

CVVH

10 mg/kg IV q24hr

CVVHD
  • 1-2 L/hr: 10 mg/kg IV q24hr
  • 3+ L/hr: 10 mg/kg IV q12hr

IV Dosing: Acute Genital or Mucocutaneous HSV

Standard Dose

5 mg/kg IV q8hr

CrCL 25-50 mL/min/1.73 m²

5 mg/kg IV q12hr

CrCL 10-24 mL/min/1.73 m²

5 mg/kg IV q24hr

CrCL <10 mL/min/1.73 m² or HD

2.5 mg/kg IV q24hr

CVVH

5 mg/kg IV q24hr

CVVHD
  • 1-2 L/hr: 10 mg/kg IV q24hr
  • 3+ L/hr: 10 mg/kg IV q12hr

IV Dosing: HSV Prophylaxis

Standard Dose

5 mg/kg IV q12hr

CrCL 10-24 mL/min/1.73 m²

5 mg/kg IV q24hr

CrCL <10 mL/min/1.73 m² or HD

2.5 mg/kg IV q24hr

CVVH or CVVHD

5 mg/kg IV q24hr

PO Dosing: Herpes Zoster, Varicella Zoster

Standard Dose

800 mg PO five times daily

CrCL 10-24 mL/min/1.73 m²

800 mg PO TID

CrCL <10 mL/min/1.73 m² or HD

400 mg PO BID

PO Dosing: HSV Prophylaxis

Standard Dose

400 mg PO BID

CrCL <25 mL/min/1.73 m² or HD

200 mg PO BID