Guidelines
Target Trough Selection

Target Trough Selection

Determine Goal Trough Concentration, Choose One:

  • skin and soft tissue infection
  • urinary tract infection
  • bloodstream or line infections due to Coagulase Negative Staphylococci (CoNS)
  • infections due to Enterococci spp
  • any other infection not specified in goal 15-20 mg/L category
  • any obese patient as defined by BMI greater than 30 kg/m²
  • any patient on renal replacement therapy or dialysis
  • deep-seated or sequestered infections (e.g. abscess) and/or invasive infections where antibiotic penetration may be compromised/decreased (e.g. CNS infections, osteomyelitis, empyema etc.)
  • pneumonia due to MRSA or HAP/VAP (where MRSA suspected or confirmed)
  • other infections due to S. aureus with vancomycin MIC greater than or equal to 1 mg/L