Hemodynamically unstable or severe infection

Hemodynamically unstable or severe infection

Initial Empiric Treatment

Vancomycin 25-30 mg/kg IV loading dose

Subsequent dosing frequency depends on renal function. Continue vancomycin until susceptibility are available.


Duration of Therapy

  • Infective endocarditis has been excluded
  • No implanted prostheses are present
  • Follow up blood cultures drawn 2-4 days after the initial set are sterile
  • The patient defervesces within 72 hours of initiation of effective antibiotic therapy
  • No evidence of metastatic infection is present on examination

Longer treatment duration is needed for patients who have complicated Staphylococcus aureus bacteremia. Strongly consider consultation with Infectious Diseases.