Levofloxacin
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (EGFR)

0 - 20 eGFR

750mg IV/PO load then 500mg IV/PO q48h

20 - 50 eGFR

500-750mg IV/PO q48h

50+ eGFR

500-750mg IV/PO daily

Intermittent Dialysis

750mg IV/PO load then 500mg QHD

Continuous Dialysis

750mg IV/PO load then 500mg IV/PO q48h