Lower respiratory infection (CAP, HAP), intraabdominal infection, UTI
Monitor QTc in patients with increased risk
QTc prolongation
Dysglycemia
CNS toxicity including confusion, psychosis
Tendinopathy and rupture
GI upset
Weakness exacerbation in myasthenia gravis
Rash
Other QTc prolonging agents
Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption
NSAIDs - increase seizure risk
Warfarin - increased INR
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 7.0
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
FDA Black Box warning against use in uncomplicated UTI, acute bacterial sinusitis, and acute exacerbation of chronic bronchitis where alternatives exist due to serious adverse side effects
May exacerbate muscle weakness in persons with myasthenia gravis. Avoid Use.
Antimicrobials
