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Antimicrobials
Penicillin G

Penicillin G

C difficile risk
Low
Oral Bioavailability
N/A

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

12-24 million units/day IV in 6 divided doses

Renal

eGFR 0 - 10eGFR 10 - 50eGFR > 500.5-4MU IV q12h0.5-4MU IV q8h0.5-4MU IV q4h

Up to 2 million units IV q4h.

Administer after dialysis on HD days.

Pharmacist review recommended.

2 million units IV q4h

General Information

Common Usage

Therapy of Streptococcal and other documented susceptible infections.

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic