General Spectrum of Activity
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection
Creatine kinase weekly
GI side effects common
Myopathy including rhabdomyolysis
Statins and fibrates - Increased myopathy risk. Monitor creatine kinase or hold while on daptomycin therapy.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half life: 9 hours
CSF penetration: Poor
Lung penetration: Poor
Urine penetration: Therapeutic
Higher doses used for endovascular infection.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.