Antimicrobials
Ceftriaxone

Ceftriaxone

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

Usual dosage 1-2g IV q24h

Community-acquired pneumonia 1-2g IV q24h

Community-acquired intra-abdominal infection 1-2g IV q24h

Bacterial Meningitis OR Intra-cranial abscess 2g IV q12h

Infective Endocarditis 2g IV q12-24h

Osteomyelitis 2g IV q24h

No dosage adjustments required

General Information

Ceftriaxone is commonly used as empiric treatment for bacterial meningitis, community-acquired pneumonia and community-acquired intra-abdominal infections.

  • Allergy/rash

  • Phlebitis

  • Cytopenias

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis

  • Clostridium difficile associated diarrhea

Increased risk of QT prolongation in patients given both ceftriaxone and lansoprazole.

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic