Antimicrobials
Cefotaxime

Cefotaxime

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

Usual dosing 2g IV q4-12h

Intra-abdominal Infections 1-2g IV q6-8h

Spontaneous Bacterial Peritonitis 2g IV q8h

Bacterial Meningitis 2g IV q4h

eGFR 0 - 10 eGFR 10 - 50eGFR > 502g IV q24h2g IV q12h-24h2g IV q8-12h

1-2g IV q24h

Dosed after HD on dialysis days

1-2g IV q8-12h

General Information

Cefotaxime is commonly used in the treatment of bacterial meningitis, community-acquired pneumonia and intra-abdominal infections.

The spectrum of activity of cefotaxime is similar to that of ceftriaxone but requires multiple daily dosing and renal adjustment. Consider using ceftriaxone as an alternative.

  •  Allergy/rash

  •  Phlebitis

  •  Positive Coombs test

  •  Cytopenias

  •  Elevated liver enzymes

  •  Gastro-intestinal intolerance

  •  Clostridium difficile associated diarrhea

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

The spectrum of activity of cefotaxime is similar to that of ceftriaxone but requires multiple daily dosing and renal adjustment. Consider using ceftriaxone as an alternative.