Lipid formulations of Amphotericin B carry lower risk of infusion related reactions, nephrotoxicity and electrolyte disturbances than Amphotericin B deoxycholate.
Monitor electrolytes and volume status closely. Pre- and post-infusion hydration with 500mL normal saline can reduce risk of renal injury.
Lipid formulations of Amphotericin B have poor urinary penetration.
DO NOT mistake lipid based Amphotericin B for Amphotericin B deoxycholate - FORMULATIONS ARE NOT INTERCHANGEABLE