Amphotericin B is often used as fungicidal therapy for various invasive fungal infections.
Daily serum CBC, creatinine and electrolytes, including magnesium levels, and liver enzymes.
Infusion related symptoms including fever, rigors, nausea, emesis and headache.
Electrolyte abnormalities, including hypokalemia and hypomagnesemia with loss of bicarbonate may occur.
Nephrotoxicity
Anemia
Phlebitis
Use of concomitant nephrotoxins may increase risk of nephrotoxicity.
Concomitant use of digoxin can increase risk of digoxin toxicity and hypokalemia.
Antimicrobial class: Antifungal - Polyene
Pregnancy category: B
Average serum half life: 24 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Monitor electrolytes and volume status closely. Pre- and post-infusion hydration with 500mL normal saline can reduce risk of renal injury.
DO NOT mistake Amphotericin B deoxycholate for lipid based Amphotericin B - FORMULATIONS ARE NOT INTERCHANGEABLE
Antimicrobials
