Antimicrobials
Amphotericin B Deoxycholate

Amphotericin B Deoxycholate

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

This antimicrobial is currently protected in Saskatoon, Southeast, and Athabasca areas. Use is restricted to Infectious Diseases. Please consult with Infectious Diseases if this antimicrobial is indicated.

0.3-1.5mg/kg IV daily, infused over several hours.

Use must be approved by Infectious Diseases.

Discuss dosing as well as pre-medication with Pharmacy

See Additional Information

0.3-1.5mg/kg IV daily, infused over several hours.

Use must be approved by Infectious Diseases.

Discuss dosing as well as pre-medication with Pharmacy

See Additional Information

0.4-1mg/kg IV q24h, infused over several hours.

Use must be approved by Infectious Diseases.

Discuss dosing as well as pre-medication with Pharmacy

See Additional Information

General Information

Amphotericin B is often used as fungicidal therapy for various invasive fungal infections.

Daily serum CBC, creatinine and electrolytes, including magnesium levels, and liver enzymes.

Infusion related symptoms including fever, rigors, nausea, emesis and headache.

Electrolyte abnormalities, including hypokalemia and hypomagnesemia with loss of bicarbonate may occur.

Nephrotoxicity

Anemia

Phlebitis

Use of concomitant nephrotoxins may increase risk of nephrotoxicity.

Concomitant use of digoxin can increase risk of digoxin toxicity and hypokalemia.

Antimicrobial class: Antifungal - Polyene

Pregnancy category: B

Average serum half life: 24 hours

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Monitor electrolytes and volume status closely. Pre- and post-infusion hydration with 500mL normal saline can reduce risk of renal injury.

DO NOT mistake Amphotericin B deoxycholate for lipid based Amphotericin B - FORMULATIONS ARE NOT INTERCHANGEABLE