Amoxicillin-clavulanate
Adult

Adult

Oral

875mg PO BID or 500mg PO TID of the amoxicillin component

IV

Usual: 1 g IV q8h of amoxicillin component (5:1 ratio) Severe infections: 2 g IV q8-12h of amoxicillin component (10:1 ratio)

1 g IV q8h (5:1 ratio) dosing sufficient for most infections. Consider increasing to 2 g IV q8-12h (10:1 ratio) in severe respiratory tract infections with abscesses