General Information


  • Prophylaxis and treatment of human and animal bite wounds
  • Polymicrobial infections involving the respiratory tract or abdomen
  • Skin and soft tissue infections

Intravenous: Use in place of piperacillin/tazobactam in the empiric treatment of the following community-acquired, polymicrobial infections:

  • Skin and soft tissue infections (e.g. animal bite or polymicrobial diabetic foot infections)
  • Bone and joint infections including osteomyelitis
  • Mild to moderate intra-abdominal infections
  • Polymicrobial respiratory tract infections (e.g. aspiration pneumonia in individuals with risk factors for anaerobes)
  • Severe odontogenic infections

Amoxicillin/clavulanate should not be used if:

  • More broad spectrum coverage is required (e.g. Pseudomonas aeruginosa, ESBL)
  • More narrow spectrum antibiotic appropriate (e.g. monomicrobial infection)
  • More affordable option is appropriate (e.g. ceftriaxone + metronidazole)

For prolonged therapy, monitor renal and hepatic function.

  • Allergy/rash
  • Cytopenias
  • Gastrointestinal intolerance
  • Clostridium difficile associated diarrhea

Allopurinol - increased risk of rash

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic