Oral:

• Prophylaxis and treatment of human and animal bite wounds
• Polymicrobial infections involving the respiratory tract or abdomen
• Skin and soft tissue infections

Intravenous: Use in place of piperacillin/tazobactam in the empiric treatment of the following community-acquired, polymicrobial infections:

• Skin and soft tissue infections (e.g. animal bite or polymicrobial diabetic foot infections)
• Bone and joint infections including osteomyelitis
• Mild to moderate intra-abdominal infections
• Polymicrobial respiratory tract infections (e.g. aspiration pneumonia in individuals with risk factors for anaerobes)
• Severe odontogenic infections

Amoxicillin/clavulanate should not be used if:

• More broad spectrum coverage is required (e.g. Pseudomonas aeruginosa, ESBL)
• More narrow spectrum antibiotic appropriate (e.g. monomicrobial infection)
• More affordable option is appropriate (e.g. ceftriaxone + metronidazole)