All aminoglycosides carry potential for tubular necrosis and renal failure, deafness due to cochlear toxicity, vertigo due to damage to vestibular organs, and rarely, neuromuscular blockade. If considering using amikacin, strongly consider ID consultation and contact Pharmacy to assist with appropriate dosing.
Perform baseline and ongoing weekly otovestibular toxicity assessment. Formal audiology assessment required if symptoms develop.
Inform patient of risk of ototoxicity and to report any symptoms.
Calculation of Dosing Body Weight (DBW)
DBW = IBW + [(ABW - IBW) x 0.4]
IBW male = 50kg + 0.906kg [Height (cm) - 152.4cm]
IBW female = 45kg + 0.906kg [Height (cm) - 152.4cm]
Dosing Body Weight = DBW
Ideal Body Weight = IBW
Actual Body Weight = ABW