Trimethoprim-Sulfamethoxazole
SMZ/TMP Renal Dosing

SMZ/TMP Renal Dosing

Dosing Weight

All dosing based on TMP component

Use total body weight to calculate dose; if obese, use adjusted body weight

Not On Dialysis

CrCl ≥30 mL/min: 5mg/kg/day divided q12h OR 160/800mg (DS) PO q12h

CrCl <30 mL/min: 2.5mg/kg/day q24h OR 160/800mg (DS) PO q24h

CrCl ≥30 mL/min: 10mg/kg/day divided q6-12h

CrCl <30 mL/min: 5mg/kg/day divided q12-24h

CrCl <15 mL/min: 3-5mg/kg/day divided q12-24h

CrCl ≥30 mL/min: 15mg/kg/day divided q6-12h

CrCl <30 mL/min: 10mg/kg/day divided q6-12h

CrCl <15 mL/min: 7.5mg/kg/day divided q12-24h

Hemodialysis (HD)

2.5-5mg/kg q24h (administer post-HD on HD days)

7.5mg/kg/day divided q12-24h (administer post-HD on HD days)

CVVHD

LD for CRRT: 10-15mg/kg (TMP)

Dose: 10mg/kg/day (TMP) divided q12h