Mycobacterial infections
Brucellosis
Osteomyelitis
Prosthetic joint infections due to Staphyloccocus aureus
Always use in combination with other agents
Lab
Clinical
Nausea/vommiting, diarrhea
Abnormal liver enzymes
Rash (Steven-Johnson syndrome)
Myopathy
Inducer of many CYP enzymes including 3A4, and 2C9.
Review patients medications carefully.
Should never be used as monotherapy.
May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.
Antimicrobial class: Antimycobacterial
Pregnancy category: C
Average serum half life: 3-4 hr
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Route of Elimination: Feces