Antimicrobials
Rifampin

Rifampin

N/A
Good (70 to 90%)
IV:$$$$ PO: $

Spectrum of Activity

Dosing

General Information

  • Mycobacterial infections

  • Brucellosis

  • Osteomyelitis

  • Prosthetic joint infections due to Staphyloccocus aureus

Always use in combination with other agents

Lab

  • Baseline and periodic LFTs

Clinical

  • Multiple drug interactions
  • Nausea/vommiting, diarrhea

  • Abnormal liver enzymes

  • Rash (Steven-Johnson syndrome)

  • Myopathy

Inducer of many CYP enzymes including 3A4, and 2C9.

Review patients medications carefully.

Should never be used as monotherapy.

May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces