Antimicrobials
Azithromycin

Azithromycin

Medium
Excellent
$

Spectrum of Activity

Dosing

General Information

  • Community acquired pneumonia
  • Pertussis
  • Upper respiratory tract infections
  • Chlamydial infections
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients
  • Monitor QTc in patients with increased risk
  • Hepatic function in patients with history of hepatic impairment
  • GI upset
  • Increased LFTs
  • QT prolongation
  • Other drugs that prolong QTc

  • Increases cyclosporine levels

  • May increase digoxin levels

  • Statins increased risk of rhabdomyolysis

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic