These guidelines are for patients without pre-existing infectious process
Administer antibiotics within 60 minutes of incision time (within 120 minutes for vancomycin and fluoroquinolones)
Decisions to follow these recommendations must be based on the judgement of the clinician and individual patient circumstances
Non-Severe - May Re-Challenge
Severe - Do Not Re-Challenge
Standardized doses recommended in the 2013 consensus guideline are appropriate for most adult patients to achieve adequate antibiotic levels above the minimal inhibitory concentration (MIC) of pathogens at the surgical site.
Successful prophylaxis requires that the antibiotic achieve goal serum and tissue concentrations at the time of incision. Administration of antibiotics too early before or too late after the time of incision will result in suboptimal tissue levels and increase the risk for post-operative wound infection.