Antimicrobials
Isoniazid

Isoniazid

Low
Moderate (40 to 70%)
$

Spectrum of Activity

Dosing

General Information

  • Active and latent TB
  • Non-TB atypicals M. kansasii

Laboratory

  • LFTs
  • For ALT or AST >3x ULN: discontinue or temporarily hold treatment

Clinical

  • Monitor for signs of hepatic dysfunction

Increased serum transaminases

Multiple CYP interactions

  • Recommended to use pyridoxine (B6) 50 mg daily
    • If diabetic 100 mg/day to prevent neuropathies
  • Consult ID