Antimicrobials
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Excellent
IV: $$$ PO: $

Dosing

General Information

  • Urinary tract infections

  • Susceptible MRSA infections

  • Stenotrophomonas infections

  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia

  • Gastrointestinal upset common

  • Bone marrow suppression

  • Hyperkalemia

  • Renal failure

  • Hepatitis

  • Aseptic meningitis

  • Stevens Johnson syndrome/toxic epidermal necrolysis

  • Other rashes

  • ACEi: increased serum potassium level
  • Increases amantadine levels
  • Decreases cyclosporine
  • Methotrexate: marrow suppression
  • Increases phenytoin
  • Increases rifampin
  • Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate