Antimicrobials
Meropenem

Meropenem

Restricted

Medium
N/A
$$$

Dosing

General Information

Pharmacy may approve Meropenem without ID approval for the following indications:

  • Documented ESBL + organism infection
  • Empiric therapy in a patient with a history of ESBL+ organism or MDRO (including resistance to Zosyn and Cefepime)

If indication falls outside of the below criteria, ID must approve its use

Therapy of serious, often nosocomial infections involving resistant gram negative organisms

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

Valproic acid: carbapenems decrease valproate levels and may decrease seizure threshold

Requires ID approval unless documented ESBL+ organism infection or use as empiric therapy in patient with history of ESBL+ or MDRO (including resistance to Pip/Tazo and Cefepime).

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic