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Pharmacy may approve Meropenem without ID approval for the following indications:
If indication falls outside of the below criteria, ID must approve its use
Therapy of serious, often nosocomial infections involving resistant gram negative organisms
Immediate and delayed-type allergy
GI disturbance
Cytopenias, positive Coombs
Liver enzyme abnormalities
Valproic acid: carbapenems decrease valproate levels and may decrease seizure threshold
Requires ID approval unless documented ESBL+ organism infection or use as empiric therapy in patient with history of ESBL+ or MDRO (including resistance to Pip/Tazo and Cefepime).
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic