Antimicrobials
Fluconazole

Fluconazole

Low
Excellent
$

Spectrum of Activity

Dosing

General Information

  • Candida infections both mucocutaneous and invasive (i.e. Candidemia)
  • Cryptococcus and Coccidioides infections
  • Antifungal prophylaxis in immunocompromised

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement

  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

  • Many via CYP450
    • Suggest review specific patient medications
  • Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics
  • Risk when combining with other QTc prolonging medications

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic