Antimicrobials
Daptomycin

Daptomycin

Restricted

Low
N/A
$$$$

Spectrum of Activity

Dosing

General Information

Targeted therapy of resistant gram positive infections with MRSA or MRSE when vancomycin inappropriate: 

  • MIC ≥2
  • Severe allergy NOT Red Man's Syndrome
  • Clinical decompensation after 3-4 days
  • Failure to clear blood culture after 7-9 days despite therapeutic vancomycin concentrations
  • VRE

Creatine kinase weekly

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

  • Myopathy including rhabdomyolysis

  • Statins and fibrates: increased myopathy
  • Monitor creatine kinase or hold while on daptomycin therapy
  • ID consult required
  • Higher doses used for endovascular infection
  • Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection

Antimicrobial class: Cyclic Lipopeptide.

Pregnancy category: B

Average serum half life: 9 hours

Urine penetration: Therapeutic

Lung penetration: Poor

CSF penetration: Poor