Spectrum of Activity


General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites

Monitor QTc in patients with increased risk

  • QTc prolongation

  • CNS toxicity including confusion, psychosis

  • Dysglycemia

  • Tendinopathy and rupture

  • GI upset

  • Rash

  • Retinal detachment

  • Weakness exacerbation in myasthenia gravis

  • CYP1A2 inhibitor: multiple interactions possible
  • QTc prolongation: increased risk with other agents that prolong QTc
  • Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds): decreased absorption
  • Cyclosporine: increased levels of cyclosporine
  • Warfarin: increased INR
  • Methadone: lowered seizure threshold

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic