Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate
$

Spectrum of Activity

Dosing

General Information

  • Community acquired pneumonia

  • Pertussis

  • Upper respiratory tract infections

  • Chlamidial infections

  • Mycobacterial infections

  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Monitor QTc in patients with increased risk

  • Prolongation of QTc interval
    • Association with increased cardiovascular mortality in observational studies
  • Prolonged half life may contribute to macrolide resistance
  • Other drugs that prolong QTc

  • Increases cyclosporine levels

  • May increase digoxin levels

  • Statins increased risk of rhabdomyolysis

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing (e.g. Salmonella species)

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic