Treatment and prophylaxis of influenza
Rare
Common
Severe
ECMO and CRRT generally do not affect the probability of target attainment with standard doses of oseltamivir. Because the elimination pathway for the active metabolite, oseltamivir carboxylate, relies heavily on tubular secretion, anuric patients receiving CRRT/ECMO experience a several-fold increase in drug concentration; thus, higher than standard doses are not necessary
Antimicrobial class: Neuraminidase inhibitor
Pregnancy category: C
Average serum half life: 2 hours
Lung penetration: Therapeutic