Antimicrobials
Clindamycin

Clindamycin

High
Excellent
IV: $$$ PO: $

General Information

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta-lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Laboratory

  • Not routinely indicated

Clinical

  • Hypersensitivity
  • GI effects
  • Photosensitivity
  • Diarrhea
  • C. difficile
  • Muscle relaxants, e.g., atracurium, baclofen, diazepam
  • St. Johns Wort

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor