Antimicrobials
Ceftriaxone

Ceftriaxone

High
N/A
$/$$

General Information

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Empiric therapy of hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Empiric therapy of spontaneous bacterial peritonitis

Laboratory

  • CBC, CMP weekly
  • Consider more frequent liver enzymes in patients with biliary disease

Clinical

  • Hypersensitivity
  • Diarrhea
  • Other GI effects
  • Signs of biliary sludge
  • Signs of gallstones
  • GI effects
  • Hypersensitivity reactions
  • C. difficile
  • Biliary sludging
  • Gallstones

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic