Trimethoprim-Sulfamethoxazole

C difficile risk
Low
Oral Bioavailability
Excellent

Dosing

PO: 1-2 DS tabs PO BID

IV: 15-20mg/kg/day of TMP IV in 4 divided doses

eGFR 0 - 10eGFR 10 - 30eGFR > 30Not recommended.

If necessary 5mg/kg/day.50% of usual dosingUsual dosing

5-10mg/kg of TMP IV q24h

2.5-10mg/kg of TMP IV q12h depending on indication

General Information

  • Urinary tract infections

  • Susceptible MRSA infections

  • Stenotrophomonas infections

  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  • Gastrointestinal upset common

  • Bone marrow suppression

  • Hyperkalemia

  • Renal failure

  • Hepatitis

  • Aseptic meningitis

  • Stevens Johnson syndrome/toxic epidermal necrolysis

  • Other rashes

ACEi - Increased serum potassium level

Increases amantadine levels

Decreases cyclosporine

Methotrexate - Marrow suppression

Increases phenytoin

Increases rifampin

Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

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