C difficile risk
Oral Bioavailability


100mg IV load on day 1 then 50mg IV q12h

Severe Impairment - Child Pugh C 100mg load on day 1 then 25mg IV daily

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

Avoid or use with caution in patients with tetracycline reactions.

GI side effects very prominent with significant nausea and vomiting.

Tetracycline related adverse events: photosensitivity, acute pancreatiti.

Rash, abnormal liver enzymes.

Oral contraceptives less effective.

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

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