Piperacillin-Tazobactam

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

3.375-4.5g IV q6h

eGFR 0 - 20eGFR 20 - 40eGFR > 402.25g IV q8h3.375g IV q8h3.375g IV q6h

eGFR 0 - 20eGFR 20 - 40eGFR > 402.25g IV q6h3.375g IV q6h4.5g IV q6h

2.25g IV q8h, 0.75g IV after dialysis

4.5g IV q6h

General Information

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  • Pneumonia

  • Intra-abdominal/hepatobiliary

  • UTI

  • Polymicrobial skin and soft tissue infection

  • Febrile neutropenia

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Incr. levels of methotrexate

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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