Oxacillin

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

2 gm IV q4h

2 gm IV q6h

General Information

  • Mostly used for MSSA infections

  • Drug of choice for CNS MSSA infection

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

  • May increase serum methotrexate levels

  • May DECREASE INR in patients receiving warfarin

  • Can cause phlebitis if given peripherally.

  • Central line preferred for tolerance.

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 30 minutes

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Metabolism: Hepatic

Route of Elimination: Bile and urine

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