Oseltamivir

C difficile risk
None
Oral Bioavailability
Excellent

Dosing

Immunocompromised or critically ill 75mg PO BID x 5 days or longer

Prophylaxis 75mg PO daily

eGFR 10 - 30eGFR > 3075mg PO daily75mg PO BID

30mg PO load then 30mg PO after each HD session for 5 day period

75mg PO q24h

General Information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant interactions

Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic

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