Norfloxacin

C difficile risk
High
Oral Bioavailability
Moderate

Dosing

400mg PO BID

eGFR 0 - 30eGFR > 30400mg PO q24h400mg PO q12h

400mg PO daily

General Information

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Monitor QTc in patients with increased risk

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

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