Nitrofurantoin

C difficile risk
Low
Oral Bioavailability
Excellent

Dosing

Cystitis Macrobid 100mg PO BID

eGFR 0 - 50eGFR > 50ContraindicatedMacrobid 100mg po BID

Contraindicated

Contraindicated

General Information

Uncomplicated cystitis in females with normal renal function

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Antacids decrease absorption

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: None

CSF penetration: None

Biliary penetration: None

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