Levofloxacin

C difficile risk
High
Oral Bioavailability
Excellent

Dosing

500-750mg PO/IV daily

eGFR 0 - 20eGFR 20 - 50eGFR > 50750mg once then 500mg PO/IV q48h750mg PO/IV q48h750mg PO/IV daily

750mg IV/PO load then 500mg q48h

750mg IV load then 500mg daily

May increase if larger flow rate

General Information

  • Lower respiratory infection (CAP, HAP)

  • Intraabdominal infection

Monitor QTc in patients with increased risk.

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

  • Other QTc prolonging agents

  • Divalent cations - Decreased absorption

  • NSAIDs - Increase seizure risk

  • Warfarin - Increased INR

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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