Imipenem

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

eGFR 0 - 30 eGFR 30 - 50eGFR ≥ 50500mg q12h500mg IV q8h500mg IV q6h

250-500mg IV q12h

500mg IV q8h

General Information

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

  • CNS effects including confusional states and seizures

  • May decrease serum concentrations of valproic acid

  • Ganciclovir/Valganciclovir - May increase risk of seizures

  • Cyclosporine - May enhance neurotoxic effects of imipenem

Antimicrobial class: Carbapenem

Average serum half life: 1.0

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